Cancer Chemical Biology, Ph.D.

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Department: Molecular Biosciences

Major Contacts, Deadlines, and Delivery Information

This Major shares core requirements with the Cancer Biology, Ph.D. ; Cancer Immunology and Immunotherapy, Ph.D. ; Integrated Mathematical Oncology, Ph.D. .

The Cancer Chemical Biology Major consists of focused training in Cancer Medicinal Chemistry and Chemical Biology. Students will also receive interdisciplinary training in the broader field of chemistry & biology through coursework and immersion in the Moffitt Cancer Center’s research endeavors. Cancer drug design and discovery will be the key component of the curriculum. The research focuses are (1) design and synthesis of chemical probes to modulate oncogenic targets and pathways, and development of selective chemical probes into novel anticancer drug candidates; and (2) to identify, validate, and characterize targets with therapeutic relevance in refractory and metastatic malignancies.

This Major will provide students a unique foundation of knowledge and practical experience in the rapidly advancing arena of cancer chemical biology. Students will also train alongside individuals studying other areas of cancer biology, providing a unique opportunity to study in a multidisciplinary and highly translational research environment. Graduates of this major will be positioned to enter the technological workforce ready to discover novel probes to unravel the mechanisms underlying oncogenesis and develop innovative anticancer drugs.

The Major is a joint endeavor between the Moffitt Cancer Center and the University of South Florida. Moffitt Cancer Center is located on the campus of the University of South Florida and is a leading institution of basic research, clinical research, and patient treatment with a focused mission “to contribute to the prevention and cure of cancer.” The Moffitt Cancer Center is officially designated as a Comprehensive Cancer Center by the National Cancer Institute of the National Institutes of Health.

Major Research Areas
The main research areas include:
•Design and synthesize chemical probes to modulate oncogenic targets and pathways
•Develop potent chemical probes into novel anticancer drug candidates
•Identify, validate, and characterize new targets with therapeutic relevance in refractory and metastatic malignancies using selective chemical probes

Admission Information

Must meet University Admission and English Proficiency requirements as well as requirements for admission to the major, listed below.

Extensive background in field of chemistry, medicinal chemistry, biochemistry, or pharmaceutical sciences
GRE optional
Advanced coursework and research experience preferred

Stipends

All Cancer Chemical Biology Ph.D. students in good standing will receive a highly competitive stipend. All students also receive student health insurance coverage and direct payment in full of all required tuition and required fees. Please visit the Program’s website for current stipend levels.

Curriculum Requirements

All students are required to successfully complete all curriculum requirements of the Cancer Chemical Biology Major. Dissertation Committees may require students to take additional course work if needed to correct deficiencies. Students are required to achieve a minimum grade of B-minus in all Shared Core Requirements, Other Required Courses and the required elective course and maintain an overall GPA of 3.00 (B) in order to remain in good standing.

Total Minimum Hours: 96 credit hours

Shared Core Requirements – 4 credit hours
Other Required Courses – 16 credit hours
Electives – 3 credit hours
Additional Requirements – 15 credit hours
Dissertation - 24 credit hours
Other Requirements – 34 credit hours

Shared Core Requirements (4 Credit Hours)

PCB 6230 Cancer Biology I - Basics of Molecular Oncology Credit Hours: 3
PCB 6932 Bioethics for Cancer Researchers Credit Hours: 1

Other Required Courses (16 Credit Hours)

PCB 6930 Current Topics in Cancer Biology Credit Hours: 2 (8 Credits for this program)
BSC 6875 Cancer Drug Discovery Credit Hours: 3
BSC 6457 Modern Basic Tools of Research Credit Hours: 2
And one of the following:
CHM 6263 Advanced Organic Chemistry II: Physical-Organic Credit Hours: 3 OR
PCB 6231 Cancer Biology II - Immunology and Applied Biology Credit Hours: 4 OR
PCB 6205 Cancer Biology III - Cancer Genomics and Drug Discovery Credit Hours: 3

Electives* (3 Credit Hours)

*Graduate Courses not on this list may be used with the approval of the Graduate Director.

CHM 6250 Advanced Organic Chemistry I: Synthesis Credit Hours: 3
BCH 6746 Structural Biology Credit Hours: 3

Additional Requirements: (15 Credit Hours)

PCB 6910 Cancer Biology Lab Rotations Credit Hours: 1-3
BSC 7911 Directed Research in Cancer Biology Credit Hours: 1-12 (4-8 credits for this program)
And one of the following:
PCB 6931 Advances in Cancer Biology Research Credit Hours: 2 (4-12 credits for this program) OR
PCB 6934 Advances in Cancer Chemical Biology Credit Hours: 2 (4-12 credits for this program) OR
PCB 6936 Advances in Tumor Immunology and Cancer Research Credit Hours: 2 (4-12 credits for this program)

Qualifying Exam

The required qualifying exam consists of a written research proposal and an oral defense of the proposal by the student.

Dissertation (24 Credit Hours)

Prior to the dissertation defense, students must have an original first-author research report accepted for publication in a peer reviewed scientific journal.

BSC 7980 Dissertation: Doctoral Credit Hours: 2-19 (24 credits for this program)

Other Requirements (34 Credit Hours)

Remaining credit hours required to meet the 96 hour minimum for graduation will consist of additional Dissertation hours (BSC 7980 Dissertation: Doctoral ), BSC 6939 Selected Topics in Cancer Biology , and/or Program approved electives.

During the first year, students will be required to complete laboratory rotations according to their interest. Laboratory rotations are 10 weeks each. Students doing rotations will need to enroll in the laboratory rotation course. If a student has not chosen a major professor after two semesters, they may enroll in an additional summer rotation. Rotations have several purposes. The foremost is to help the students choose a compatible major professor and an exciting research project. A second purpose is for students to develop necessary technical skills. Students will be evaluated by the host professor and the Graduate Advisor will assign a grade to each student at the end of the semester.